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The SOD1 E40K Missense Mutation follows classic Mendelian inheritance. Carriers with a single recessive allele typically appear normal but pass the mutation to 50% of gametes.
A carrier-to-carrier cross yields a 25% statistical risk per offspring of inheriting two mutant alleles, potentially causing lethal developmental defects or expressing homozygous health anomalies.
Yes, commercial veterinary genomic panels can sequence the specific locus to eliminate guesswork before pairing breeding stock.