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The baseline clinical toxicity threshold is approximately 5 mg/kg. Doses approaching or exceeding 5x this threshold represent critical or life-threatening exposure.
Primary mechanism: Piperidine alkaloid block of nicotinic receptors resulting in ascending motor paralysis. Symptoms typically manifest in gastrointestinal, cardiovascular, or central nervous systems depending on absorbed bioavailability.
Emesis must NEVER be induced if the patient is already showing neurological symptoms (ataxia, tremors, seizures), is comatose, has ingested caustic/corrosive agents, or is a species incapable of vomiting (e.g., horses, rabbits, rodents).