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The baseline clinical toxicity threshold is approximately 3 mg/kg. Doses approaching or exceeding 5x this threshold represent critical or life-threatening exposure.
Primary mechanism: Microtubule polymerization inhibitor arresting cell division across all organ systems. Symptoms typically manifest in gastrointestinal, cardiovascular, or central nervous systems depending on absorbed bioavailability.
Emesis must NEVER be induced if the patient is already showing neurological symptoms (ataxia, tremors, seizures), is comatose, has ingested caustic/corrosive agents, or is a species incapable of vomiting (e.g., horses, rabbits, rodents).